Apple's Balance Sheet Essay Example | Topics and Well Written Essays - 750 words

Apple's Balance Sheet - Essay Example Resources From the gave money related data to Apple for the two six months working periods taken in 2008 and 2009, plainly the organization encountered an upward development in various things with respect to resources. Introductory money and its counterparts for the two indicated periods speak to a huge degree of decrease from USD 11.875b in 2008 to USD 4.466b in 2009 (Apple, 2009). While money and comparable money things development couldn't really speak to development taking into account liquidity common sense issues, it is proper to make the suspicion that the materiality of the distinction didn't influence the general impression of business activities as income esteems show. This contention is likewise upheld by the perception of expanded transient attractive protections over a similar period by twofold from USD 10.236b to USD 20.547b which could clarify the reflected liquidity distinction. In spite of the way that the records receivable after important compromise modifications g ive a decrease in 2009, the distinction indicates a colossal contrast as far as tasks. Held inventories additionally show a decrease that would be clarified by tasks when request projections would be scaled downwards in the midst of money related emergency. In any case, by and large fluid resources mirrored a development of USD 1.542b (from USD 32.311b to USD 33.853b), which gives a superior reflection that the organization developed its fluid resources. Interest in type of long haul protections gives detail of fixed resources and the expansion from USD 2.379b to USD 3.865b (37 percent) affirms the present resources pattern as a development direction (Apple, 2009). Other fixed resources components, for example, structures and properties possessed expanded from USD 2.546b to USD 2.455b, a reflection additionally reflected in the class of different resources that rose from USD 2.498b to USD 1.935b. To affirm this pattern, the general resource figure was a development of 9.3 percent (U SD 43.237b from USD 39.572b). On the side of this data, maybe the organization can counsel certain coincidental data of income nature to feature the clear development in resources and activity level. The estimation of pay and other working exercises demonstrate upward developments in net gain (USD 2.81b from USD 2.626b) similar to the compromise developments for money producing exercises. Certain working ideas, for example, deterioration and amortization outline an ascent in the charged qualities, which deciphers in development of the related resources. An expansion in the estimation of these activity costs for example for devaluation from USD 222m in 2008 to USD 330m per year later mirrors a colossal climb of related resource base to help tasks of the enterprise. In different developments, expanded stock-based pay cost by 45 percent (USD 242m to USD 351m) means that development in tasks that event stock-based remunerations, interpreted as development by the organization. It is obvi ous that this data mirrors an amazing appropriateness of Apple as a speculation goal. In spite of the way that such increment in pay could likewise show wastefulness in tasks at the equivalent working limit, the decrease of air misfortunes from USD 10m in 2008 to USD 8m in 2009 also

Capital Structure Pre and Post Global Financial Crisis Dissertation

Capital Structure Pre and Post Global Financial Crisis - Dissertation Example At the point when obligation financing is concerned, it incorporates getting from the banks, money related renting, and security giving in the security advertise. Value financing predominantly establishes the held profit and giving of extra offers in the securities exchange. Capital structure has its own significance in an organization. There are essential two reasons supporting this reality. Right off the bat, obligation and value having contrasts in the expenses, in the loan costs, and the necessary paces of return, there emerges a need have a suitable blend of obligation and value that can boost the estimation of the firm by decreasing the all out expense of the organization. This is feasible through the capital structure of the organization (Broyles, 2003, pp.303-304). Furthermore the information and comprehension of capital structure demonstrates significant since the acquiring of capital has an impact on the money related danger of the firm. The unpredictability of the net gain or profit per portion of an organization increments with the intrigue installments that speak to extra fixed costs for the organization. This thusly builds the installment of interests on the giving of bonds. The expense of value capital likewise increments in the securities exchange because of acquiring. Every one of these components may in the end lead an organization to money related trouble or hazard that prompts the expanding requirement for a proper capital structure (Broyles, 2003, p.304). ... essential point of the examination is to assess the capital structure of firms in the UK before the worldwide monetary emergency in the years around 2007 and after the budgetary emergency in the years 2011 or 2012. So as to accomplish the previously mentioned point of the investigation, the accompanying destinations have been thought of: Review hypotheses on capital structure so as to decide how it may change during a time of delayed downturn and liquidity emergency. Look into the capital structure of open UK organizations in 2007 and in 2011/2012. Assess the degree to which any adjustments in capital structure are because of the continuous worldwide emergency. Capital Structure: An Understanding towards the Effect of Economic Crisis: There are four essential speculations identified with capital structure of a firm. These are: Net Income Theory of Capital Structure: This hypothesis weights on a firm’s capacity to pick a capital structure where the degree of offer capital or va lue is not exactly the obligation of the firm. This causes a firm to expand its fairly estimated worth and along these lines decline the weighted normal expense of capital of the organization. On the off chance that the substance of the obligation in the capital structure blend is high, it is alluded as money related influence expanding which builds the estimation of the firm (Theories of Capital Structure, 2010). Accordingly it very well may be comprehended that when there is a financial emergency winning in a nation, the accessibility of the obligation lessens that influences the apportion of the obligation to value and subsequently the capital structure of a firm would modify therefore. Net Operating income Theory of Capital Structure: According to this hypothesis, the idea of expanding money related influence doesn't exist. It accepts that changing the capital structure of a firm doesn't acquire any change the general monetary expense and estimation of the

Cymbalta Withdrawal Symptoms, Timeline & Treatment

Cymbalta Withdrawal Symptoms, Timeline & Treatment Depression Treatment Medication Print How Long Does Withdrawal From Cymbalta Last? By Corinne O’Keefe Osborn linkedin Corinne Osborn is an award-winning health and wellness journalist with a background in substance abuse, sexual health, and psychology. Learn about our editorial policy Corinne O’Keefe Osborn Medically reviewed by Medically reviewed by Steven Gans, MD on August 29, 2019 Steven Gans, MD is board-certified in psychiatry and is an active supervisor, teacher, and mentor at Massachusetts General Hospital. Learn about our Medical Review Board Steven Gans, MD on August 29, 2019 Verywell / Emily Roberts More in Depression Treatment Medication Causes Symptoms Diagnosis Types Childhood Depression Suicide In This Article Table of Contents Expand Overview Signs & Symptoms Coping & Relief Warnings Long-Term Treatment Resources View All Back To Top Cymbalta (duloxetine) is a prescription medication used to treat depression, anxiety, fibromyalgia, and diabetic neuropathy. It is what’s known as a serotonin and norepinephrine reuptake inhibitor (SNRI. SSNRIs have a powerful effect on the brain, working to increase the activity of neurotransmitters called serotonin and norepinephrine. When SNRIs are discontinued, some people experience withdrawal symptoms. Overview When you quit Cymbalta, it can take your brain some time to adjust to being without it. During this time, you may notice some dizziness and flu-like symptoms. Headaches, nausea, and vomiting are all common in the days and weeks following your last dose of Cymbalta. More distressing symptoms include nightmares or disturbing dreams, and a pins and needles sensation that comes and goes throughout the body.?? Although these symptoms are typically mild, they can be alarming when they come as a surprise. Most people are not warned about the potential for withdrawal symptoms when they stop taking antidepressants. If your doctor did warn you, they may have used the term “antidepressant discontinuation syndrome,” which can be a bit misleading. A pooled analysis of six different placebo-controlled research studies found that 44.3% of people quitting duloxetine (Cymbalta) reported withdrawal-like symptoms, compared to 22.9% of people in the placebo group. The most commonly cited symptom was dizziness, followed by nausea and headache.?? The majority of participants in the duloxetine (Cymbalta) studies categorized their symptoms as either mild or moderate. Among those experiencing withdrawal symptoms, about 65% said that their symptoms went away in about one week.?? Signs Symptoms When you stop taking Cymbalta, your brain has to adjust to lower levels of serotonin and norepinephrine. It can take days or weeks for your brain to settle into its new normal. During this time, you may experience a number of symptoms, including:?? dizzinessnauseavomitingpins and needlesnightmaresanxietystrange sensations like brain zapstrouble sleepingirritability Symptoms typically appear within two to four days of stopping your dose and last for a few weeks.?? While taperingâ€"slowly decreasingâ€"your dose is a common treatment strategy, some research suggests that even with this strategy, you still may experience some withdrawal symptoms.?? Compared to other SNRIs, like venlafaxine, Cymbalta withdrawal is relatively mild.?? If you have read elsewhere about an intense withdrawal syndrome from SNRIs, the authors were most likely referring to venlafaxine (Effexor).     There is one report of a withdrawal seizure?? and one report of withdrawal symptoms coming and going over a period of ten months.??   Coping Relief To help make it easier to come off Cymbalta, your doctor will likely recommend a taper lasting at least two weeks. Tapering a medication means working with your doctor to develop a plan to take progressively smaller doses of a drug over an extended period of time. It is unclear whether or not a slow Cymbalta taper will always prevent withdrawal symptoms, but it is generally considered the safest way to stop an antidepressant.   Work with your doctor to develop a tapering schedule that fits your needs. Your doctor may want to switch you to a different antidepressant or provide medical support for your withdrawal symptoms. Other ways to ease the withdrawal experience include:   Working with a therapist. Talk therapy can help ease anxiety, soothe irritability, and even reduce physical discomfort.Seeking support from friends and family. Letting your loved ones know that you are experiencing withdrawal symptoms can help prevent conflict and reduce confusion.Practicing self-care. It is important to keep your body and brain in good shape by eating healthy and working out at least three times per week.Trying herbal remedies. If you are having trouble sleeping, try taking an OTC supplement like valerian root or melatonin at bedtime.Treating pain and nausea. You can treat headaches and stomachaches with OTC pain relivers and anti-nausea medications.  Avoiding relapse. If you see signs that your depression or anxiety is coming back, talk to your doctor about alternative treatment options.     Warnings Although quitting Cymbalta cold turkey is rarely dangerous, it is best to consult your doctor before attempting to do so. Tell your doctor why you are interested in quitting and ask about tapering options.   Long-Term Treatment After Cymbalta, you may require ongoing treatment. The nature of that treatment will depend on a variety of factors, including the state of your mental health and your reasons for stopping the medication. Unlike other medications, like antibiotics, that work for almost everyone, antidepressants can be really hit-or-miss. A medication that your friend calls a lifesaver, might make you too dizzy to play with your kids or too foggy to work. Brain chemistry is an incredibly complex system involving not only neurotransmitters like serotonin, but also nerve cells, genes, and brain structures. If it were as easy as turning up the dial on one neurotransmitter and turning down the dial on another, depression would be much easier to treat. That said, if Cymbalta didn’t work for you, ask your doctor to recommend something else. Treating depression can involve a process of trial and error. If you are quitting Cymbalta because you feel your depression has lifted, that’s fantastic. But it is important that you keep in touch with your psychiatrist or therapist to be sure that stopping the medication doesn’t cause a reemergence of your depression. Depression is a disease with a very high reoccurrence rate. About 50% of people who recover from one episode of depression will have more depressive episodes in their lifetime. If you have had more than one episode, there is about an 80% chance you will have another.?? If you have had one or more episodes of severe depression, you may be a good candidate for maintenance therapy. Typically, this means continuing with a therapeutic dose of antidepressants to reduce the risk of relapse. Other forms of maintenance therapy include psychotherapy.?? In the meantime, keep an eye out for symptoms that your depression is returning. Common symptoms include:?? feeling sad, empty, or hopelessexperiencing outbursts of tearfulness, anger, or frustrationlosing interest, pleasure, or excitement for enjoyable activitiessleeping too much or too littlefeeling tired all the timefeeling worthless or guiltyfixating on perceived failures or faultsfeeling anxious, agitated, or restlessmoving, speaking, or thinking slowlythoughts of death or suicide Resources If you or someone you love is experiencing suicidal thoughts, call the National Suicide Prevention Lifeline (1-800-273-8255). You will be connected with staff or volunteers at a crisis center near you. The people on the other end of the line can help you calm down and figure out what to do next. If your doctor isn’t helping, consider finding a new psychiatrist, psychologist, or therapist in your area. The Substance Abuse and Mental Health Services Administration (SAMHSA) has a searchable directory of qualified providers. You can also call them at 1-800-662-HELP (4357).   If you have health insurance, you can also search the company’s list of local providers who accept your insurance. A Word From Verywell If you gave Cymbalta a good try but you still don’t feel like yourself, don’t give up. There are other medications, doses, and combinations of medications that you can try. If you don’t think you need medication anymore, that’s great, but don’t neglect your mental health. A qualified therapist can help bolster the effects of antidepressants and help prevent a relapse. Just like medications, there is no once-size-fits-all therapist. Keeping trying until you find a combo that works for you.   How to Taper Off Your Antidepressants

The Importance of Hospitality Illustrated in Homers...

Far removed from our individualistic society today is the ancient Greece portrayed in The Odyssey, by Homer, where hospitality and good will are the way of things. As decreed by Zeus himself, those who wish the favor of the Gods must welcome foreign and domestic with hospitality. A man was supposed to offer the best of his food, his home, and his knowledge before ever asking for his guest’s name or why he was there. There is a sense that those of high status are the main givers of hospitality, but they are not the only ones commanded to offer hospitality. Homer emphasizes hospitality from everyone during Telemachus’ and Odysseus’ journeys, using a man’s xenos, host/guest relationships, with his guest to infer his integrity and character.†¦show more content†¦Telemachus is made to be the standard by which we can judge the following instances of hospitality or lack there of. He is rewarded for his kindness too. In this way, Homer can subtly teach us the virtues that he believes define a man’s character by giving them good fortune. Athena gives Telemachus hope of his father returning and tells him how to find out more from Pylos and Sparta. They set off together to gain knowledge of his father and to give us a dose of good hospitality. Telemachus’ journey brings him to Pylos, where King Nestor welcomes him with open arms as he â€Å"[sits] them down at the feast on fleecy throws† (Homer, 3. 40-1). King Nestor is instantly assumed to be a good-hearted man, because he has fulfilled the first step in proper hospitality. Next, he asks of Telemachus all the questions a good host would care to know and Telemachus’ questions in return prove that he trusts Nestor to help him in his quest to find his father. Nestor offers Telemachus a comfortable stay, gives praise to Odysseus, and treats Telemachus with all the respect of a fellow king. Homer exemplifies Nestor’s honor, because he and his son welcome d Telemachus without knowing who he was until after the feast. This is most likely why all hospitable hosts will not ask for a name or a purpose until they have met their guests’ needs: it is proper to do so. An interesting thing to note is Nestor’s insight into Agamemnon’sShow MoreRelatedGrecian Identity Essay1512 Words   |  7 Pagesatmosphere of Greece. With time, however, the people of Greece began to strive toward a collective identity. The political environment began to solidify toward a populist view. These occurrences and changes of the culture are illustrated in the works of Homer’s The Iliad and The Odyssey, and Hesiod’s Works and Days, as well as the Aeschylus’ The Persians. These collective writings depict the progression of Grecian culture through the eventual unification of its identity and its government. The Iliad,Read MoreHospitality in the Quran1690 Words   |  7 PagesIdeas on Cultural Hospitality in the Quran The virtues within the Qur’an regarding hospitality and generosity seem to be a product of the landscape of pre- Islamic Arabia. Indeed, the arid environment and tribal configuration of the society required that neighbors help each other, strangers or travelers be given food, and wealth be distributed evenly throughout the clan. The communities that settled along the trade routes of the Arabian Peninsula relied on merchants returning to their community

Genes And Their Effects On Gene Editing Essay - 1428 Words

Gene editing is one of the most researched fields of molecular biology, as manipulated genes deem possible studying the specific genes and their effects. In the past, there were several attempts to manipulate gene function, including homologous recombination, RNA interference (RNAi), zinc-finger nucleases (ZFNs) and transcription-activator like effector nucleases (TALENs). These past approaches are expensive and time-consuming to engineer as opposed to Crispr Cas9, limiting their widespread use. What the Crispr Cas9 technique offers, and biologists desire, is specificity: the ability to target and study particular DNA sequences in the expanse of a genome with ease of preparation as used in Fu et al. (2014) and Korkmaz et al. (2016). The Crispr Cas9 system requires only the redesign of the crRNA to change the target specificity. This aspect of the Crispr Cas9 differs from the other genome editing tools, including ZFNs and TALENs, in which engineering the protein-DNA interface is required. Furthermore, Crispr Cas9 enables rapid genome-wide search of gene function by generating large gRNA libraries. The rapid progress in developing Cas9 into a set of tools for molecular biology research has been remarkable most likely due to the simplicity, high efficiency and versatility of the technique. Of the designer nuclease systems currently available for precision genome engineering, the Crispr Cas9 system is by far the most user-friendly according to Korkmaz et al. (2016). In theirShow MoreRelatedDelivery Of The Cas Components1306 Words   |  6 Pagesmethods of transfection such as microinjection, gene gun, electroporation, sonoporation, and using viruses such as adenoviruses and lentiviruses. In cultured mammalian cells, researchers have used electroporation, nucleofection, and Lipofectamine mediated transfection methods to deliver vectors expressing the gene for gRNAs and Cas9 endonuclease. In cultured human and mouse cells, Lentiviral vectors have also been used as a mode of delivery of genes. In addition to animal models and cell lines, Cas9Read MoreGenetic Disorders ( Genetic Disease Foundation ) Essay1607 Words   |  7 Pagesrange from memory loss to blindness, physical abnormalities and more. A process known as gene editing was created in an attempt to do away with genetic disorders. Gene editing was named â€Å"Science Magazine s Breakthrough of the Year 2015† due to its ease and high accessibility (ScienceDirect). It works by using CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and Cas9 to make changes in the genes of cells. Francisco Mojica discovered CRISPR in 1993 at the University of Alicante inRead MoreThe Consequences Of Gene Editing With CRISPR-Cas 91116 Words   |  5 Pages 4 Future Possibilities 4.1 Gene Editing with CRISPR-Cas 9 This technology was discovered in 2013 and very quickly applied to human cells in a laboratory setting. This technology has set the record in all the editing methods to control the genetic makeup of an offspring (Sas Lawrenz, 2017). This record is helped by the ability of CRISPR-Cas9 to replicate any gene in the human genome by using 20 bases. This method uses a RNA strand (CRISPR), the bases, and an endonuclease (Cas 9). The Cas 9 intentionallyRead MoreSingle Nucleotide Polymorphisms Essay1514 Words   |  7 Pagesmay be associated with genetic disease, most of which lie in non-coding regulatory elements. As only ~1% of human genes are protein coding, it may hardly be surprising that so many of these implicated features are found within non-coding regions. The task we must face now is to assess the impact and prevalence of each of these variants which may lead to breakthroughs in how disease genes are localised and mapped in different individuals and populations. GWAS is a powerful tool for identifying trendsRead MoreGreat Power, Great Responsibility1390 Words   |  6 PagesGreat Power, Great Responsibility Chances are you have or know someone that has a family member suffering from Alzheimer s disease. It’s effects are heartbreaking and awful for all involved, but what if Alzheimer s disappeared from the world? Due to recent technological innovations, gene editing could soon be used to cure genetic diseases like Alzheimer s. In the film Jurassic Park the character Dr. Ian Malcolm said â€Å"... scientists were so preoccupied with whether or not they could that theyRead MoreThe Use Of Crispr / Cas9 Gene Editing1507 Words   |  7 Pages The practical uses for CRISPR/Cas9 gene editing and other nuclease gene editing methods extend to animals as well. There are many proposed uses of the technology that need to be considered according to their associated risks and benefits. The first of which is the use of CRISPR to knock out genes associated with horn development in dairy cattle (Cima, 2016). Animals with horns present a hazard to animals kept in the same enclosure as them an d to the workers that handle them. Only a small percentageRead MoreA New Science Of Genetic Engineering Essay1130 Words   |  5 Pagesimpending future. He worried as to how the public would react to his life work. The growing potential of gene editing is sweeping the US, filled with both overwhelming hope as well as fear. This is a bridge which must be crossed to achieve trust within the biomedical community. To ensure the people this can bring great change without the unethical byproducts which could come with gene editing. Much of the American public is divided with the relatively new science of genetic engineering due to concerningRead MoreViable Capable To Be Used In An Experiment Essay1297 Words   |  6 Pages Viable- Capable to be used in an experiment Vitro fertilization- Creating embryos from a petri dish Germline editing- The act of revising the cells of an embryo Bioethicist- An individual who studies aspects of biology, such as gene editing Cleave- To cut or remove in a swift motion Genome- As said by the author of the article, Tina Hesman Saey, â€Å"...that make up the human genetic instruction book, or genome,† to paraphrase, a genome entails the genetic circumstances of an embryo or otherRead MoreI Am Kaylyn Stewart From The University Tech University1164 Words   |  5 PagesKaylyn Stewart One Gene at a Time Scene: Ted Talk I am Kaylyn Stewart from the KAS research center. I have a bachelors in biological science from Louisiana Tech University and I’m in the process of getting my masters in biomedical engineering. At KAS, we are currently gathering research on the world’s top new promising technology known as genome editing. Our goal at the KAS research center is to shine the light on the advantages and disadvantages of genome editing around the world and provideRead MoreGenome Editing Essay1614 Words   |  7 PagesGenome editing of germ line cells using CRISPR/Cas9 system Recent studies suggest that genome editing of germ line cells is an effective strategy for mutated gene correction in sperms and oocytes for the inhibition of onset of inherited disorder. The first time, germ line genome editing in human by CRISPR/Cas9 system , was carried out to correct mutation of HBB (Beta globin) gene in zygote of ÃŽ ²-thalassemia patients by homologous DNA recombination (HDR) [80, 81]. Embryonic genome editing utilized

Thinking Free Essays

I am thirty four years of age. I’m originally from Trinidad and Tobago W. L. We will write a custom essay sample on Thinking or any similar topic only for you Order Now Came to America twenty years ago, lived in Brooklyn New York, and attended south shore high school and graduated. I’m a very proud and active mother of five children four boys and one girl. I am truly blessed to have my kids In my life. My children play a very big part in my life they are my world. My two boys play basketball, and the other two plays football, my daughter Is a cheerleader, they also o swimming. We do a lot of traveling In the summer time; explore deferent ways of life and what life has to offer, until we ended up In the state of Pennsylvania. I have been In the medical field for over fifteen years, as a companion In homes also In hospitals now am a nurses aid, I love taking care of the elderly and the mentally challenged patients. Taking care of people I enjoy and love doing, I assist my patients with activities and dally living Including bathing, dressing, eating etc. My Job requires hours of walking, standing and heavy Lifting of patients. When I’m not working I’m cooking cleaning and spending time with my kids doing adventures things, I make sure and put that time in with my children. I am a single mother doing it on my own: I think I have the motherly part under control so far. Now I’m back in school pursing my dreams of graduating from college and getting a better paying job with my degree. My kids support my every step, and I am so excited to be back in school. How to cite Thinking, Papers

Sean Dawson Essays - Posadas, Puerto Rico, , Term Papers

Sean Dawson Bus. Law 510 July 14,1998 Posadas De Puerto Rico Associates vs. Tourism Company U.S. Supreme Court 1986 Facts:Substantive:Gambling was legalized in Puerto Rico in 1948, but prohibited advertising of casinos within Puerto Rico. 1978 the appellant, Posadas de Puerto Rico, was fined twice by the agency enforcing the antiadervertisement law. Procedural:The appellant challenged the law, claiming that it violated the appellants 1st. Amendment freedom of speech rights. The Superior Court of Puerto Rico determined that the law as applied was constitutional. The Puerto Rico Supreme Court affirmed. The U.S. Supreme Court granted certiorari. Issues:Does the legislature have the right to ban certain kinds of commercial free speech? Holdings:Yes. Rational:Since this case is regarding restriction of pure commercial speech, the court is guided by the rules set down in Central Hudson Gas & Electric Corp vs. Public Service Commission. There are four guidelines set forth in the preceding case: 1) commercial speech receives a limited form of 1st amendment protection as long as the activity is legal and not misleading, 2) comm. Speech may be restricted if the governments interest in doing so is so substantial, 3) the restriction directly advances the govt. asserted interest, and 4) the restriction is no more extensive than necessary to serve that interest. 1)The activity is legal and is not misleading. 2)In this case the government believes that the advertisement of casino games will lead to a host of criminal activity, such as: prostitution, organized crime, and will have a detrimental effect on the moral and cultural identify of the locals. 3)The advertising of casino gambling aimed at the residents of Puerto Rico would serve to increase the demand for the product advertised, thus restricting advertising would lower the demand among the locals to gamble. 4)Since casinos are not restricted when advertising to tourists, the court does not think that is more extensive than necessary.